Affiliation:
1. Russian Society of Trace Elements in Medicine, ANO “Centre for Biotic Medicine”, Moscow, Russia + Yaroslavl State University, Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl, Russia + All-Russian Research Institute of Medicinal and Arom
2. Yaroslavl State University, Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl, Russia + Orenburg State Medical University, Department of Biochemistry, Orenburg, Russia + Orenburg State University, Institute of Bioelementology (Russian Sat
3. Russian Society of Trace Elements in Medicine, ANO “Centre for Biotic Medicine”, Moscow, Russia
4. Institute of General Pathology and Pathophysiology, Laboratory of Physicochemical and Ecological Pathophysiology, Moscow, Russia
5. Orenburg State Pedagogical University, Department of Chemistry, Orenburg, Russia
6. Orenburg State Medical University, Department of Biochemistry, Orenburg, Russia + Orenburg State University, Institute of Bioelementology (Russian Satellite Centre of Trace Element -Institute for UNESCO), Orenburg, Russia
Abstract
The aim of this study was to investigate the distribution of ultratrace
elements in rat tissues and to perform a comparative analysis of hair and
serum as potential bioindicators of the total ultratrace element content.
Thirty-six male Wistar rats were fed a standard chow containing 0.006?0.000,
0.001?0.000, 0.017?0.002, 0.382?0.031, 0.168?0.014, 3.211?0.134, 0.095?0.006,
0.000?0.000, 6.675?0.336, 15.327?0.564, 0.002?0.000, and 1.185?0.202 ?g/g of
silver (Ag), gold (Au), cesium (Cs), gallium (Ga), germanium (Ge), lanthanum
(La), niobium (Nb), platinum (Pt), rubidium (Rb), titanium (Ti), thallium
(Tl)and zirconium (Zr), respectively, from weaning to 3 months old. The
ultratrace element content in the liver, kidney, muscle, heart, serum and
hair was assessed using inductively coupled plasma mass spectrometry. The
obtained data indicate that the highest concentrations of most of the studied
elements (Ti, Zr, Ge, Nb, tungsten (W), La, uranium (U), Ag, Au, Pt) are in
hair, whereas the lowest were observed in the serum. Statistical analysis
revealed a significant association between concentrations in the hair and
other tissues for Cs, Ti, Nb, Tl, La, U and Au. At the same time, serum Cs,
Rb, Ti, Ge, Nb, W, Ga, Tl and La concentrations significantly correlated with
the tissue content of the respective ultratrace elements. It can be concluded
that hair may be used as a potential bioindicator for certain ultratrace
element content in the mammalian organism.
Publisher
National Library of Serbia
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology