Affiliation:
1. Chair of Microbiology, Faculty of Biology, Belgrade
Abstract
The aim of this work was to investigate the antimutagenic potential of
monoterpenes from sage and basil in Escherichia coli. The mutagenic potential
of monoterpenes was pre-screened with Salmonella/microsome reversion assay in
strain TA100 and no mutagenic effect was detected. The antimutagenic
potential against UV- 4NQO- and t-BOOH induced mutagenesis was evaluated in
E. coli K12 and E. coli WP2 by reversion assays. The obtained results
indicate that camphor and thujone reduce UV- and 4NQO-induced mutations;
myrcene reduces t-BOOH-induced mutations, while eucalyptol and linalool
reduce mutagenicity by all tested mutagens. Considering evolutionary
conservation of DNA repair and antioxidative protection, the obtained results
indicate that further antigenotoxicity studies should be undertaken in
eukaryotes.
Publisher
National Library of Serbia
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
Cited by
12 articles.
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