Affiliation:
1. Department of Chemistry, Research and P. G. Center, Shri Chhatrapati Shivaji College, Omerga, Dist-Osmanabad, Maharashtra, India
2. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India
Abstract
The solid complexes of Mn(II), Fe(III), Co(II), Ni(II), and Cu(II) with
4-hydroxy-3-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-methyl-2H-pyran-2-one,
derived from 3-acetyl-6-methyl-2H-pyran- 2,4(3H)-dione (dehydroacetic acid)
and 4-hydroxy benzaldehyde, were synthesized and characterized by elemental
analysis, conductometry, thermal analysis, magnetic measurements, IR, 1H-NMR
and UV-VIS spectroscopy and a biological study. From the analytical and
spectral data, the stoichiometry of the complexes was found to be 1:2
(metal:ligand). The physico-chemical data suggest a distorted octahedral
geometry for the Cu(II) complexes and an octahedral geometry for all the
other complexes. The thermal decomposition of all the complexes was studied
by the TG- DTA method. The synthesized ligand and its metal complexes were
screened for their in vitro antibacterial activity against Gram negative
(Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial
strains and for in vitro antifungal activity against Aspergillus flavus,
Curvularia lunata and Penicillium notatum. The results of these studies
showed the metal complexes to be more antibacterial/antifungal against one or
more species as compared with the non-complexed ligand.
Publisher
National Library of Serbia
Cited by
14 articles.
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