Abstract
Trans-resveratrol is a phytoalexin from the stilbene class, polyphenolic
compound from non-flavonoid group. In vitro and animal studies have shown
that trans-resveratrol may exert a wide range of potential beneficial effects
to human health, which involves antioxidant, anti-inflammatory,
cardioprotective, neuroprotective, anti-diabetic and anti-cancer activity.
The objective of this paper was to summarize available data concerning the
most important clinical trials focused on resveratrol biological effects. The
results of clinical trials indicate that resveratrol has potential
cardioprotective activity in patients with increased risk of cardiovascular
disease. It can also have positive effect on the circulatory function and
exert anti-diabetic activity in humans, while the anti-cancer activity is
still insufficiently tested. Some issues remain unsolved, such as the dose
and length of treatment that would maximize the potential of resveratrol. It
is expected that future, better designed and more extensive clinical trials
will provide additional information related to this topic.
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
National Library of Serbia
Subject
Pharmacology (medical),General Medicine
Cited by
4 articles.
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