Synthesis and antibacterial activity of some Schiff base complexes

Abstract

Two Schiff bases were synthesized from raceacetophenone: 1) ADS1 4-ethyl-6-{(E)-1-[(3-nitrophenyl)imino]ethyl}benzene-1,3-diol and 2) ADS3 4-ethyl-6-[(E)-1-{(2-nitrophenyl)imino]ethyl}benzene-1,3-diol. Then their metal complexes were formed. The metals selected for the preparation of complexes were copper, nickel, iron and zinc. Hence, in total 8 metal complexes were synthesized and screened for antibacterial activity against some clinically important bacteria, such as Pseudomonas aeruginosa, Proteus vulgaris, Proteus mirabilis, Klebsiella pneumoniae and Staphylococcus aureus. The in vitro antibacterial activity was determined by the Agar Ditch technique using DMF (polar) and 1,4-dioxane (non polar) as solvents. The Schiff bases showed greater activity than theirmetal complexes; themetal complexes showed differential effects on the bacterial strains investigated and the solvent used, suggesting that the antibacterial activity is dependent on the molecular structure of the compound, the solvent used and the bacterial strain under consideration. The Schiff base ADS3 in the polar solvent DMF showed better antibacterial activity towards the investigated bacterial strains. Amongst the four metals, Zn showed the best antibacterial activity followed by Fe in 1,4-dioxane while Ni followed by Zn and Fe showed the best antibacterial activity in DMF. P. vulgaris was the most resistant bacteria.