Affiliation:
1. School of Medicine, Institute of Anatomy, Niš
2. School of Medicine, Institute for Biomedical Research, Niš
Abstract
Glomerulus is an important filtrating apparatus in the body. Three types of
cells - endothelial, mesangial and visceral epithelial cells can be
identified in the capillary tuft. Glomeruli develop during nephrogenesis
which starts in the 8th week and ends between the 32nd and 36th week of
gestation. The nephron develops through stages described as the vesicle, the
comma-shaped, S-shaped with the developing glomerulus and the mature
glomerulus. Glomerular differentiation involves the expansion of the original
capillary component into the plexus that consists of 6-8 loops and the
migration of podocytes that are arranged around these glomerular capillaries.
Glomerular capillary differentiation represents a set of developmental
changes of the glomerular endothelial and epithelial cells. The active
differentiation of glomerular capillaries starts in the hemisphere of an
inferior arm of S-shaped bodies. Endothelial precursors unite into
precapillaries devoid of lumen. Further differentiation includes the
flattening of endothelial cells on the basement membrane, the loss of
superfluous cells, the development of lumen and the formation of fenestrae.
The glomerular basement membrane is differentiated by the fusion of
epithelial and endothelial basement membrane. The differentiation of visceral
epithelial cells includes the development of cytoplasmic processes and the
flattening of cell bodies. Primary cytoplasmic processes are formed from the
podocyte bodies and develop secondary and tertiary processes or foot
processes. Foot processes from one podocyte interdigitate with foot processes
from other podocytes. In the developing glomeruli, there is a difference in
the level of differentiation of visceral epithelial cells. Cells with
differentiated foot processes and cells with no cytoplasmic processes are
observed within the same glomerulus.
Publisher
National Library of Serbia
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献