Affiliation:
1. Faculty of Technology, Leskovac
Abstract
In this review, the biosynthesis of allicin (allyl thiosulfinate) by
enzymatic transformation of alliin and various methods of its synthesis with
detailed investigation of mechanisms and kinetics are summarized. A
convenient method is also described for determination of allicin stability
and the utility of the inclusion complexes of this pharmacologically active
agent with ?-cyclodextrins in increasing its stability. Allicin is the
initial precursor for the production of ajoene ((E)- and
(Z)-4,5,9-trithiadodeca- 1,6,11-triene 9-oxides) and vinyldithiin
(2-vinyl-4H-1,3-dithiin, and 3-vinyl-4H-1,2- dithiin), which are more stable
and show various pharmacological effects. The mechanisms of allicin
transformations to these compounds are given in detail. Finally, the data on
the pharmacological effects of allicin and its transformation products,
ajoene and vinyldithiin, are presented.
Publisher
National Library of Serbia
Cited by
45 articles.
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