Allicin and related compounds: Biosynthesis, synthesis and pharmacological activity

Author:

Ilic Dusica1,Nikolic Vesna1,Nikolic Ljubisa1,Stankovic Mihajlo1,Stanojevic Ljiljana1,Cakic Milorad1

Affiliation:

1. Faculty of Technology, Leskovac

Abstract

In this review, the biosynthesis of allicin (allyl thiosulfinate) by enzymatic transformation of alliin and various methods of its synthesis with detailed investigation of mechanisms and kinetics are summarized. A convenient method is also described for determination of allicin stability and the utility of the inclusion complexes of this pharmacologically active agent with ?-cyclodextrins in increasing its stability. Allicin is the initial precursor for the production of ajoene ((E)- and (Z)-4,5,9-trithiadodeca- 1,6,11-triene 9-oxides) and vinyldithiin (2-vinyl-4H-1,3-dithiin, and 3-vinyl-4H-1,2- dithiin), which are more stable and show various pharmacological effects. The mechanisms of allicin transformations to these compounds are given in detail. Finally, the data on the pharmacological effects of allicin and its transformation products, ajoene and vinyldithiin, are presented.

Publisher

National Library of Serbia

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