Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma-Reference-Cited by-同舟云学术

Impact of epidermal growth factor receptor gene RS1468727 polymorphism on survival of the patients with oral squamous cell carcinoma

Published:2023 Issue:9-10 Volume:151 Page:572-577
ISSN:0370-8179
Container-title:Srpski arhiv za celokupno lekarstvo
language:en
Short-container-title:Srp Arh Celok Lek

Author:

Baculov Katarina¹,Djan Mihajla²^ORCID,Bajkin Branislav³^ORCID,Mijatov Ivana⁴^ORCID,Vuckovic Nada⁵^ORCID,Mijatov Sasa⁴,Djan Igor⁶,Barjaktarovic Iva¹^ORCID,Stojcevic-Maletic Jelena¹,Vucinic Natasa⁷^ORCID

Affiliation:

1. University of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, Serbia

2. University of Novi Sad, Faculty of Science, Department of Biology and Ecology, Novi Sad, Serbia

3. University of Novi Sad, Faculty of Medicine, Clinic for Dentistry of Vojvodina, Novi Sad, Serbia

4. University of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Clinic for Maxillofacial and Oral Surgery, Novi Sad, Serbia

5. University of Novi Sad, Faculty of Medicine, University Clinical Center of Vojvodina, Center for Pathology and Histology, Serbia

6. Institute of Oncology of Vojvodina, Novi Sad, Serbia

7. University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia

Abstract

Introduction/Objective. Genetic aberrations and environmental factors are known to play an important role in oral squamous cell carcinoma (OSCC). The aim of the study was to clarify the association of epidermal growth factor receptor (EGFR) gene polymorphism rs1468727 with overall survival (OS) in patients with OSCC. Methods. The study comprised a total of 61 patients diagnosed with OSCC. The follow-up period for each patient was three years from the date of surgery and during that period their genotypes for rs1468727 polymorphism of the EGFR gene were identified using real-time polymerase chain reaction. Binary logistic regression was used to investigate the influence of various variables on survival. Additionally, the ?2 test of independence and Man?Whitney U test were done to examine the interplay between two categorical variables and two independent samples. Results. Two variables demonstrated a statistically significant influence on OS: the TNM Classification of Malignant Tumors (TNM) stage and EGFR genotype. At the end of the follow-up period, 39 patients survived, with a noteworthy observation that more than half of the survivors had the EGFR rs1468727 CC genotype. The distribution of CC and CT genotypes was equal (?2 = 0.397, df = 2, p = 0.820) among patients who deceased, indicating that no statistically significant correlations were found between OS and demographic or tumor-related characteristics. Conclusion. EGFR rs1468727 homozygote (genotype CC) and TNM stage showed statistically significant influence on OS in the follow-up period. This study highlights the potential significance of homozygote EGFR rs1468727 CC in assessing the prognosis and treatment outcomes of patients undergoing surgery for OSCC.

Publisher

National Library of Serbia

Subject

General Medicine

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