Blend microspheres of poly (glycolide-co-ε-caprolactone) and ethyl cellulose for the controlled release of 5-fluorouracil

Author:

Ziane Asma1,Bakouri Hichem1,Khoukhi Oum1,Guemra Kaddour1

Affiliation:

1. Physical and Organic Macromolecular Chemistry Laboratory (LCOPM), Faculty of Exact Sciences, University of Djillali Liabes, Sidi Bel Abbes, Algeria

Abstract

In this present study, a series of copolymers with diverse compositions were produced using bulk ring-opening polymerization of glycolide and ?-caprolactone, using stannous(II) octoate as initiator. 1H, 13C NMR, and FTIR spectroscopy were used to characterize the resultant copolymers. After-wards, the oil/water emulsion evaporation technique was used to create blend microspheres of poly (glycolide-co-?-caprolactone) and ethylcellulose in order to investigate the controlled release of 5-fluorouracil, an anticancer drug. The size distribution of the microspheres was studied by optical microscope, which confirmed their spherical nature with sizes ranging from 112 to 186?m, FTIR and X-ray diffraction were used to confirm the polymer blend compatibility and to confirm the absence of drug-polymer interactions. Moreover, in vitro release experiments were performed at 37?C in simulated buffer medium of the stomach (pH=1.2) for 2h, and simulated intestinal medium (pH=7.4). It was found that the release of 5-fluorouracil from blend microspheres followed pH-independent release as compared to that of plain poly(?-caprolactone) and ethylcellulose microspheres for more than 10h. Furthermore, to better understand the nature of the drug release profiles, release data was fitted to empirical models.

Publisher

National Library of Serbia

Subject

General Engineering

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