Affiliation:
1. Department of Organic Chemistry, Andhra University, Visakhapatnam, India
2. Department of Chemistry, Gitam Institute of Science, GITAM University, Visakhapatnam, India
Abstract
A series of eight novel 2-amino-4-(substituted phenyl)-6-(7"- methoxy,
3",4"-dihydro, 2",2"-dimethyl-2H-benzopyran) pyrimidines were designed and
synthesized by utilizing benzene-1,3-diol as starting material. The
structures of the isolated products (6a-h) were established through 1HNMR,
13C-NMR, and FT-IR spectroscopic techniques and elemental analysis. The
synthesized compounds were utilized for screening antimicrobial properties
against gram positive (Bacillus pumilus, Bacillus subtilis, Streptococcus
faecalis), gram negative bacteria (Enterococcus faecalis, Escheria coli,
Proteus vulgaris) and fungi (Pencillian expasom, Aspergillus niger, Candida
albicans) using Ampicillin and Ketoconazole. Most of the compounds showed
moderate to high antibacterial and antifungal activities against studied
strains with inhibition zones between 8 and 30 mm.
Publisher
National Library of Serbia
Cited by
1 articles.
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