Synthesis and characterization of new 2-amino-4-(substituted phenyl)-6-(7’’-methoxy, 3’’,4’’-dihydro, 2’’,2’’-dimethyl-2hbenzopyran) pyrimidines and their bio evaluation

Author:

Murthy Y.L.N.1,Suhasini Padma1,Anjali Jha2

Affiliation:

1. Department of Organic Chemistry, Andhra University, Visakhapatnam, India

2. Department of Chemistry, Gitam Institute of Science, GITAM University, Visakhapatnam, India

Abstract

A series of eight novel 2-amino-4-(substituted phenyl)-6-(7"- methoxy, 3",4"-dihydro, 2",2"-dimethyl-2H-benzopyran) pyrimidines were designed and synthesized by utilizing benzene-1,3-diol as starting material. The structures of the isolated products (6a-h) were established through 1HNMR, 13C-NMR, and FT-IR spectroscopic techniques and elemental analysis. The synthesized compounds were utilized for screening antimicrobial properties against gram positive (Bacillus pumilus, Bacillus subtilis, Streptococcus faecalis), gram negative bacteria (Enterococcus faecalis, Escheria coli, Proteus vulgaris) and fungi (Pencillian expasom, Aspergillus niger, Candida albicans) using Ampicillin and Ketoconazole. Most of the compounds showed moderate to high antibacterial and antifungal activities against studied strains with inhibition zones between 8 and 30 mm.

Publisher

National Library of Serbia

Subject

General Chemistry

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