The synthesis and antimicrobial study of some azetidinone derivatives with the para-anisidine moiety-Reference-Cited by-同舟云学术

The synthesis and antimicrobial study of some azetidinone derivatives with the para-anisidine moiety

Published:2007 Issue:5 Volume:72 Page:437-442
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Bhat Ishwar¹,Chaithanya Sunil¹,Satyanarayana P.D.¹,Kalluraya Balakrishna²

Affiliation:

1. Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Mangalore University, Mangalagangothri, India

2. Department of Studies in Chemistry, Mangalore University, Mangalagangothri, India

Abstract

Azetidinones were synthesized from p-anisidine in two steps. First the Schiff's bases were prepared by reacting the hydrazide of an anisidine derivative with different aromatic aldehydes. Cyclocondensation of the Schiff's bases with chloroacetyl chloride in the presence of triethylamine resulted in the formation of the corresponding azetidinone analogues. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis. The antibacterial and antifungal potential of the synthesized compounds were evaluated by the agar disc method.

Publisher

National Library of Serbia

Subject

General Chemistry

Reference1 articles.

1. Syntheses and Anti-inflammatory Activities of Substituted Arylamino-(N′-benzylidene)acetohydrazides and Derivatives

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