Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans

Abstract

Introduction/Objective. Somatosensory evoked potentials are a neurophysiological tool for testing the effects of drugs in humans and animals. The aim of this study was to estimate the way that bromazepam and ibuprofen had on tooth pulp-evoked potentials (TPEPs) after non-painful stimuli, as well as to detect possible differences in this activity. Methods. Sixty young healthy subjects were included in the study. They were arranged into three groups: ibuprofen, bromazepam, and placebo. To record TPEPs response, dental pulp were electrically stimulated through intact enamel with non-painful stimuli. For stimulation and registration we used Xltek Protektor 32 system, software EPWorks, version 5.0 (Natus Medical Incorporated, Oakville, ON, Canada). The experiment consisted of two testing sessions. Five recordings were performed in each session. The first test session was before, and the second was 45 minutes after administration of a single dose of the ibuprofen (400 mg), bromazepam (1.5 mg) or placebo. Results. The results of the present study exhibit that both ibuprofen and bromazepam significantly increased all the latencies; ibuprofen decreased amplitudes of all the waves except the first one (p < 0.05), and bromazepam decreased amplitudes of all the waves except the first one (p < 0.05); placebo did not modified TPEPs waves (p > 0.05). Additionally, there were no significant differences in influence on TPEPs between bromazepam and ibuprofen (p > 0.05). Conclusion. Our study showed that both bromazepam and ibuprofen had the same influence on TPEPs after non-painful stimuli. That indicates that anxiolytic dose of bromazepam affects neurotransmission in the same manner as non-opioid analgesics ibuprofen.