Family-Based Association Study of the MTHFR Polymorphism C677T in Patients with Nonsyndromic Cleft Lip and Palate from Central Europe-Reference-Cited by-同舟云学术

Family-Based Association Study of the MTHFR Polymorphism C677T in Patients with Nonsyndromic Cleft Lip and Palate from Central Europe

Published:2008-05 Issue:3 Volume:45 Page:267-271
ISSN:1055-6656
Container-title:The Cleft Palate-Craniofacial Journal
language:en
Short-container-title:The Cleft Palate-Craniofacial Journal

Author:

Reutter Heiko¹,Birnbaum Stefanie¹,Lacava Amalia Diaz²,Mende Meinhard²,Henschke Henning²,Bergé Stefaan³,Braumann Bert⁴,Lauster Carola⁵,Schiefke Franziska⁶,Wenghoefer Matthias⁷,Saffar Mitra⁴,Reich Rudolf⁷,Scheer Martin⁸,Kramer Franz-Josef⁹,Knapp Michael²,Mangold Elisabeth¹

Affiliation:

1. Institute of Human Genetics, University of Bonn, Bonn, Germany.

2. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.

3. Deparment of Maxillo-Facial Surgery, Radboud Universiteit Nijmegen, Nijmegen, The Netherlands.

4. Department of Orthodontics, University of Cologne, Köln, Germany.

5. Department Maxillo-Facial Surgery, University of Berlin, Berlin, Germany.

6. Department of Maxillo-Facial Surgery, University of Leipzig, Leipzig, Germany.

7. Department of Maxillo-Facial Surgery, University of Bonn, Bonn, Germany.

8. Department of Maxillo-Facial Surgery, University of Cologne, Köln, Germany.

9. Department of Maxillo-Facial Surgery, University of Göttingen, Göttingen, Germany.

Abstract

Objective: The 677C→T allele in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been implicated in the etiology of nonsyndromic cleft lip and palate (CL/P). This study involved a family-based association study of the MTHFR polymorphism. Patients/participants: We examined 181 patients with CL/P of central European descent and their parents for this variant. Results: The transmission disequilibrium test (TDT) did not confirm an association between the MTHFR 677C→T polymorphism and nonsyndromic CL/P as previously suggested (p = .36). When comparing the offspring of mothers with periconceptional use of folate to those without, no statistically significant differences were found (p = .708). Conclusion: Our data suggest that the MTHFR 677C→T polymorphism does not make a major contribution to the occurrence of CL/P among central Europeans.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Oral Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1597/06-174

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