Erucic acid treatment in lipopolysaccharide-induced anxiety and depression using ADMET properties / behaviour paradigms / interleukins pathways in rats

Author:

Sayyed N.,Hafeez A.,Kumar U.,Deva V.,Ahmad S.,Kazmi I.

Abstract

The neuroimmune system plays a vital role in the etiology of anxiety and depression. In the current research, the aim was to investigate erucic acid's ability to counteract depression and anxiety induced by lipopolysaccharide (LPS) in rats. Erucic acid is known to have anti-inflammatory properties, and it was hypothesized that it would be able to reduce the inflammation and stress associated with LPS-induced anxiety and depression. The rats were distributed into five groups (n = 6). The impact of erucic acid with the dose administration of 10 and 20 mg/kg on anxiety depression-like behaviour was studied using the elevated plus maze test, staircase test, marble-burying behaviour, open field test, hyper emotionality, force swimming, and tail suspension test. Also, the biochemical parameters including cytokines i.e., interleukin-6 (IL-6) and IL-10 were performed. Swiss ADME, pkCSM, and ProTox-II served as as an integrated online platform for precise and complete predictions to determine ADME/T properties of erucic acid. LPS significantly increased anxiety and depression-like behaviour in rats. Erucic acid reduced the lengthening in time of immobility on LPS administration in the tail suspension test and forced swim test indicating the antidepressant type of action. Anti-anxiety effects of erucic acid were increased time spent in the open arms in the elevated plus maze test, decreased repetitive behaviors in the staircase test, marble-burying, and hyper emotionality tests. The high LD50 value (1.382) indicates that erucic acid is relatively non-toxic in acute oral exposures in rats. Erucic acid also prevented LPS-induced elevation of IL-6 and restored the IL-10 levels. It was demonstrated that erucic acid significantly attenuates LPS-induced depression and anxiety in rats. These findings suggest that erucic acid has potential antidepressant and anxiolytic effects, possibly through modulation of the neuroimmune system and inflammatory response. Erucic acid may be beneficial for neuropharmacological effects like anxiety and depression. Additionally, erucic acid may have potential benefits in treating other neurological disorders, such as Alzheimer's disease and Parkinson's disease. Further research is needed to better understand the potential therapeutic applications of erucic acid in neurological disorders.

Publisher

Oles Honchar Dnipropetrovsk National University

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3