Identification and Evaluation of Potentially Genotoxic Agricultural and Food-related Chemicals

Author:

Hayashi Makoto1,Honma Masamitsu2,Takahashi Motoko3,Horibe Atsuko4,Tanaka Jin1,Tsuchiya Mai1,Morita Takeshi2

Affiliation:

1. Public Interest Incorporated Foundation, BioSafety Research Center, 582-2, Shioshinden, Iwata, Shizuoka, 437-1213, Japan

2. National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya, Tokyo, 158-8501 Japan

3. Incorporated Administrative Agency Food and Agricultural Materials Inspection Center, 2-772, Suzuki-cho, Kodaira, Tokyo, 187-0011, Japan

4. Food Safety Commission Secretariat, 22nd Fl., Akasaka Park Bld., 5-2-20, Akasaka, Minato-ku, Tokyo, 107-6122, Japan

Publisher

Food Safety Commission, Cabinet Office

Reference33 articles.

1. 1. European Chemicals Agency (ECHA), CMR substances from Annex VI of the CLP Regulation registered under REACH and/or notified under CLP − a first screening, ECHA-12-R-01-EN, May 2012 Available at: http://echa.europa.eu/documents/10162/13562/cmr_report_en.pdf.

2. 2. European Food Safety Authority (EFSA), Opinion of the Scientific Committee on a request from EFSA related to A Harmonised Approach for Risk Assessment of Substances Which are both Genotoxic and Carcinogenic, The EFSA Journal (2005) 282, 1–31. Available at: http://www.efsa.europa.eu/en/efsajournal/pub/282.htm.

3. 3. OECD 1997. OECD Guidelines for the Testing of Chemicals. Bacterial reverse mutation test (TG 471). Available at: http://www.oecd-ilibrary.org/environment/test-no-471-bacterial-reverse-mutation-test_9789264071247-en.

4. 4. Kirkland D, Pfuhler S, Tweats D, et al. How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: report of an ECVAM workshop. Mutat Res. 2007; 628(1): 31–55.

5. 5. OECD 1997. OECD Guidelines for the Testing of Chemicals. Mammalian Erythrocyte Micronucleus Test (TG 474). Available at: http://www.oecd-ilibrary.org/environment/test-no-474-mammalian-erythrocyte-micronucleus-test_9789264071285-en.

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