Fabrication, Characterization and Toxicity Evaluation Chemically Cross Linked Polymeric Material: A Proof of Concept

Abstract

Background: Natural mucilage is a highly beneficial biodegradable polymeric material. Natural mucilage is non-toxic, biodegradable and easily available. Aim: The current study is required to determine the properties of a basil seed mucilage-based polymeric network and its toxicity. Method: By using potassium persulfate (KPS) as an initiator, microwave-assisted synthesis, a green approach was used to produce a graft copolymer of a polymeric blend of Basil seed mucilage (BSM) and acrylamide (AM). Variable amounts of AM and KPS were used to optimize the best grade based on the highest percentage of grafting efficiency, and the results were investigated using intrinsic viscosity measurement, Fourier Transformation infrared spectroscopy (FTIR), DSC, H-NMR spectra, and X-ray diffraction. The degree of swelling is determined by the concentration of mucilage, monomer, and the density of crosslinking in the polymeric network.  Result: The microwave irradiation process with potassium persulfate as the redox initiator is a visible, green, and cost-effective method. The BSM-4 batch showed 464% grafting and 107.23 % grafting efficiency. FTIR, DSC, H-NMR, and XRD analysis showed results about completing the grafting process and changes in functional groups. The BSM-4 batch proved that the basil seed mucilage polymeric network is safe for oral drug delivery of BCS class II and IV drugs. The findings of the toxicity study indicate that the developed polymeric network is safe and non-toxic, and it may eventually prove to be a superior option for many established and cutting-edge drug delivery methods when administering drugs orally. Conclusion: In conclusion, the Basil seed mucilage-based polymeric network will encourage long-term delivery of any BCS Class II or IV drug, and acute toxicity testing proved that the mucilage-based network is secure for oral drug delivery.