Affiliation:
1. From the Institute of Pharmacology and Toxicology, Consejo Superior de Investigaciones Científicas, Department of Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Abstract
Abstract
Objectives
To determine pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after a single IV and IM administration of enrofloxacin and tissue residues after serial daily IM administration of enrofloxacin in pigs.
Animals
20 healthy male pigs.
Procedure
8 pigs were used in a crossover design to investigate pharmacokinetics of enrofloxacin after a single IV and IM administration (2.5 mg/kg of body weight). Twelve pigs were used to study tissue residues; they were given daily doses of enrofloxacin (2.5 mg/kg, IM for 3 days). Plasma and tissue concentrations of enrofloxacin and ciprofloxacin were determined. Residues of enrofloxacin and ciprofloxacin were measured in fat, kidney, liver, and muscle.
Results
Mean (± SD) elimination half-life and mean residence time of enrofloxacin in plasma were 9.64 ± 1.49 and 12.77 ±2.15 hours, respectively, after IV administration and 12.06 ± 0.68 and 17.15 ± 1.04 hours, respectively, after IM administration. Half-life at α phase of enrofloxacin was 0.23 ± 0.05 and 1.94 ± 0.70 hours for IV and IM administration, respectively. Maximal plasma concentration was 1.17 ± 0.23 µg/ml, and interval from injection until maximum concentration was 1.81 ± 0.23 hours. Renal and hepatic concentrations of enrofloxacin (0.012 to 0.017 µg/g) persisted for 10 days; however, at that time, ciprofloxacin residues were not detected in other tissues.
Conclusions and Clinical Relevance
Enrofloxacin administered IM at a dosage of 2.5 mg/kg for 3 successive days, with a withdrawal time of 10 days, resulted in a sum of concentrations of enrofloxacin and ciprofloxacin that were less than the European Union maximal residue limit of 30 ng/g in edible tissues. (Am J Vet Res 1999;60:1377–1382)
Publisher
American Veterinary Medical Association (AVMA)
Subject
General Veterinary,General Medicine
Cited by
1 articles.
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