Avapritinib versus Placebo in Indolent Systemic Mastocytosis

Author:

Gotlib Jason1,Castells Mariana2,Elberink Hanneke Oude3,Siebenhaar Frank45,Hartmann Karin67,Broesby-Olsen Sigurd8,George Tracy I.9,Panse Jens1011,Alvarez-Twose Iván12,Radia Deepti H.13,Tashi Tsewang14,Bulai Livideanu Cristina15,Sabato Vito16,Heaney Mark17,Van Daele Paul18,Cerquozzi Sonia19,Dybedal Ingunn20,Reiter Andreas21,Pongdee Thanai22,Barete Stéphane23,Ustun Celalettin24,Schwartz Lawrence25,Ward Brant R.25,Schafhausen Philippe26,Vadas Peter27,Bose Prithviraj28,DeAngelo Daniel J.29,Rein Lindsay30,Vachhani Pankit31,Triggiani Massimo32,Bonadonna Patrizia33,Rafferty Mark34,Butt Nauman M.35,Oh Stephen T.36,Wortmann Friederike37,Ungerstedt Johanna38,Guilarte Mar39,Taparia Minakshi40,Kuykendall Andrew T.41,Arana Yi Cecilia42,Ogbogu Princess43,Gaudy-Marqueste Caroline44,Mattsson Mattias45,Shomali William1,Giannetti Matthew P.46,Bidollari Ilda47,Lin Hui-Min47,Sulllivan Erin47,Mar Brenton47,Scherber Robyn47,Roche Maria47,Akin Cem48,Maurer Marcus45

Affiliation:

1. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA

2. Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Harvard Medical School, Boston

3. Department of Allergology, University Medical Center, Groningen Research Institute Asthma and COPD, University of Groningen, Groningen, the Netherlands

4. Institute of Allergology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin

5. Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, Berlin

6. Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland

7. Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland

8. Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark

9. Associated Regional and University Pathologists, Inc. Laboratories, Department of Pathology, University of Utah School of Medicine, Salt Lake City

10. Department of Oncology, Hematology, Hemostaseology, and Stem Cell Transplantation, University Hospital Aachen, Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany

11. Center for Integrated Oncology, Aachen, Bonn, Cologne, Düsseldorf (ABCD), Aachen, Germany

12. Institute of Mastocytosis Studies of Castilla-La Mancha, Virgen del Valle Hospital, Toledo, Spain

13. Guy’s & St. Thomas’ National Health Service Foundation Trust, London

14. Huntsman Cancer Institute, University of Utah, Salt Lake City

15. Department of Dermatology, Centre of Reference for Mastocytosis, Toulouse University Hospital, Toulouse, France

16. Department of Immunology, Allergology and Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium

17. Department of Medicine, Columbia University Medical Center, New York

18. Department of Internal Medicine and Immunology, Erasmus Medical Center, Rotterdam, the Netherlands

19. Department of Medicine, University of Calgary, Calgary, AB, Canada

20. Department of Hematology, Oslo University Hospital, Oslo

21. Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany

22. Division of Allergic Diseases, Mayo Clinic, Rochester, MN

23. Unit of Dermatology, Centre of Reference for Mastocytosis, Pitié-Salpêtrière Hospital, Assistance Publique–Hôpitaux de Paris, Sorbonne Université, Paris

24. Department of Internal Medicine, Division of Hematology, Oncology and Cell Therapy, Section of Bone Marrow Transplantation and Cellular Therapy, Rush Medical College, Chicago

25. Virginia Commonwealth University, Richmond, VA

26. Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

27. Department of Medicine, Division of Clinical Immunology and Allergy, St. Michael’s Hospital, University of Toronto, Toronto

28. Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston

29. Dana-Farber Cancer Institute, Boston

30. Department of Medicine, Duke University School of Medicine, Durham, NC

31. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

32. Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy

33. Allergy Unit and Asthma Center, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy

34. The Beatson West of Scotland Cancer Centre, Glasgow, Scotland

35. The Clatterbridge Cancer Centre, Bebington, Wirral, United Kingdom

36. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, Washington University, St. Louis

37. Oberärztin Hämatologie/Onkologie bei Uksh Campus Lübeck, Universitätsklinikum Schleswig-Holstein, Universität zu Lübeck, Lübeck, Schleswig-Holstein, Germany

38. Department of Medicine, Huddinge (H7), Karolinska University Hospitale, Stockholm

39. Hospital UniversitariVall d’Hebron, Institut de Recerca Vall d’Hebron (VHIR), Barcelona

40. University of Alberta, Edmonton, AB, Canada

41. Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL

42. Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ

43. Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, University Hospitals Rainbow Babies and Children’s Hospital, Case Western Reserve University School of Medicine, Cleveland

44. Service de Dermatologie et de cancérologie cutanée, Assistance Publique–Hopitaux de Marseille, Aix-Marseille Université, Marseille, France

45. Department of Hematology, Uppsala University Hospital and Department of Immunology, Genetics and Pathology, Uppsala, Sweden

46. Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Boston

47. Blueprint Medicines Corporation, Cambridge, MA

48. University of Michigan, Ann Arbor, MI

Publisher

Massachusetts Medical Society

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