Chemical profiling of fern Cheilosoria mysurensis (Wall. ex Hook.) Ching & Shing and its biological activity

Abstract

Cheilosoria mysurensis (Wall. ex Hook.) Ching & Shing, a medicinal fern traditionally used to treat burns, throat pain and bone fracture. There is no any scientific report regarding anticancer studies of this species. The aim of the study was to find out the chemical components through GC/MS analysis with their antioxidant and cytotoxic activity. GC-MS analysis shows primary ingredients viz, Cis-9, 10-epoxyoctadecan-1-ol and Oxiraneundecanoic acid, 3-pentyl-, methyl ester, trans were present. High free-radical scavenging activity has been discovered in 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and showed the IC50 value of 52.13±0.33. Furthermore, C. mysurensis also showed good cytotoxic effects against DLA and EAC cell lines with values of 72.9% and 79.5% at 200 µg/ml dose respectively. Overall findings suggested that the identified chemical compounds proved to be rich in antioxidant property. Further, this fern can be a good resource for pharma industry to produce novel anti-cancer drugs.