Affiliation:
1. Institute of Biology, Federal Research Center Komi Science Center of the Ural Branch of the Russian Academy of Sciences
2. Institute of Molecular Biology named after V.A. Engelhardt of the Russian Academy of Sciences
Abstract
Aging is accompanied by a widespread deterioration in the state of the body (physiological and psychological) with the concomitant manifestation of neurodegenerative diseases (dementia, Alzheimer’s disease, Parkinson’s disease). Biologically active substances contained in the fruits of chokeberry have previously shown a neuroprotective potential in relation to model organisms in vivo, so we put forward a hypothesis about the possible neurodenegeroprotective potential of the ethanol extract of chokeberry (×Sorbaronia mitschurinii) on Drosophila melanogaster with overexpression of the precursor of human beta-amyloid UAS-Aβ42. Its accumulation in human brain cells triggers the development of Alzheimer’s disease. In this work, we have studied the effect of chokeberry extract at a concentration of 10 mg/ml on the lifespan of Drosophila model of Alzheimer’s disease. The extract increases the median and maximum lifespan of females by 11 %, as well as the median lifespan of males by 2 % but reduces their maximum lifespan by 3 %. These results indicate the neuroprotective effect of chokeberry extract.
Subject
General Earth and Planetary Sciences,General Energy