Affiliation:
1. Bashkir State Medical University
2. Stavropol State Medical University
3. Republican Dermatovenerologic Dispensary
Abstract
The review highlights the power and prospects of confocal laser scanning microscopy in cutaneous cancer diagnosis. This non-invasive technology allows optical skin sectioning at a varying depth with no special tissue treatment or staining. This diagnostic method is currently considered the most promising in imaging and assessment of superficial skin neoplasms. It enables a deeper investigation of skin structures at higher beam powers, which, however, implies possible skin damage. Recent technological advances in the field facilitated the development of new, portable, more practical personal confocal laser scanning microscopy devices providing for an efficient and deeper imaging of skin lesions less accessible otherwise. The technology enables a multiple repeated visualisation of the same skin spot at different time intervals for monitoring the neoplasm progression, therapy impact and cancer dynamics in skin. Numerous studies have determined the basic confocal properties of various tumoural lesions and showed a good correlation with dermatoscopy and histology data. This diagnostic technique allows a multiple non-damaging examination of same skin area, as well as the monitoring of tumourigenesis, clinical dynamics and treatment outcome.
Publisher
Bashkir State Medical University
Subject
General Engineering,Energy Engineering and Power Technology
Reference49 articles.
1. Ilie M.A., Caruntu C., Lupu M., Lixandru D., Tampa M., Georgescu S.R., et al. Current and future applications of confocal laser scanning microscopy imaging in skin oncology. Oncol Lett. 2019;17(5):4102–11. DOI: 10.3892/ol.2019.10066
2. Volkov I. A., Frigo N. V., Znamenskaya L. F., Katunina O. R. Application of confocal laser scanning microscopy in biology and medicine. Vestnik Dermatologii i Venerologii. 2014;90(1):17–24 (In Russ.). DOI: 10.25208/0042-4609-2014-90-1-17-24
3. Peppelman M., Wolberink E.A., Gerritsen M.J., van de Kerkhof P.C., van Erp P.E. Application of leukotriene B4 and reflectance confocal microscopy as a noninvasive in vivo model to study the dynamics of skin inflammation. Skin Res Technol. 2015;21(2):232–40. DOI: 10.1111/srt.12181
4. Batani A., Brănișteanu D.E., Ilie M.A., Boda D., Ianosi S., Ianosi G., et al. Assessment of dermal papillary and microvascular parameters in psoriasis vulgaris using in vivo reflectance confocal microscopy. Exp Ther Med. 2018;15(2):1241–6. DOI: 10.3892/etm.2017.5542
5. Ghita M.A., Caruntu C., Rosca A.E., Caruntu A., Moraru L., Constantin C., et al. Real-time investigation of skin blood flow changes induced by topical capsaicin. Acta Dermatovenerol Croat. 2017;25(3):223–7. PMID: 29252175