12R-HETE Acts as an Endogenous Ligand of Nur77 in Intestine and Regulates ILC3s Plasticity

Author:

Huang Ning ning,Li Hao,Ye Ling,Peng Jian,Wei Hongkui

Publisher

Elsevier BV

Reference42 articles.

1. Fretland and Djuric, 1989), but analysis using SPR revealed that 12R-HETE has a stronger binding capacity to Nur77 than 12S-HETE and the known exogenous natural agonist Csn-B. Moreover, 12R-HETE demonstrates a stronger activation of the transcriptional regulatory activity of Nur77 than 12S-HETE. 12R-HETE can regulate intestinal ILC3s expansion and plasticity in a Nur77-dependent manner. In contrast, 12S-HETE lacks this ability. Other studies have also recognized significant differences in the biological functions of 12R-HETE and 12;Hsu;Nur77 does not have an identified endogenous ligand,1981

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