Synergistic PTEN Restoration and CXCR2 Depletion with a Bone-Targeting Lipid Nanocomposite Inhibits Drug-Resistant CRPC Metastasis to Bone

Author:

Gong Luyao,Chen Jiyuan,Song Guanshan,Wang Yuanyuan,Wang Yunxia,Ding Weihong,Peng Yeheng,Lou Yan-Ru,Murtola Teemu J.,Xu Ke,Gao Yuan

Publisher

Elsevier BV

Reference35 articles.

1. Afterwards, TUNEL staining was used to detect tumor cell apoptosis. The GB4-BPL@siCXCR2/pPTEN group displayed an elevated number of apoptosis cells in comparison to the other groups. Notably, no TUNEL-positive cells were observed in the PBS groups (Figure S17A);Survival of the GB4-BPL@siCXCR2/pPTEN group was also longer than that of the PBS group (p < 0.01) and the single-agent groups (p < 0.05) (Figure 5E)

2. CA: A;R L Siegel;Cancer Journal for Clinicians,2023

3. Immune system and intestinal microbiota determine efficacy of androgen depletion therapy against prostate cancer;S Terrisse;Journal of Clinical Oncology,2022

4. SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer;J Chen;Theranostics,2020

5. Castration-resistant prostate cancer: Many treatments, many options, many challenges ahead;Jar Garcia;Cancer,2011

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