Cyclotron production of 101Pd/101mRh radionuclide generator for radioimmunotherapy-Reference-Cited by-同舟云学术

Cyclotron production of 101Pd/101mRh radionuclide generator for radioimmunotherapy

Published:2011-05-01 Issue:2 Volume:76 Page:131-135
ISSN:2195-8580
Container-title:Kerntechnik
language:en
Short-container-title:

Author:

Enferadi M.¹,Sadeghi M.²,Ensaf M.²

Affiliation:

1. Department of Nuclear Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

2. Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, P.O. Box: 31485/498, Karaj, Iran

Abstract

Abstract 101mRh is one of such radionuclides that has been considered as a potential candidate for targeted radiotherapeutic use, due to its nuclear decay and chemical properties. Electrodeposition of rhodium metal on a copper backing was performed in acidic sulphate. The target was bombarded with a current intensity of 120 μA (Ep = 29 → 25 MeV) for 30 min (60 μAh). Radiochemical methods were investigated to optimize the production of no-carrier-added 101Pd/101mRh. The use of a cyclotron target with radiochemical processes (i.e. electrodeposition, electrodissolution and ion-exchange column chromatography) were carried out to produce this radionuclide in high-specific activity and radiochemical form suitable for radiopharmaceutical syntheses.

Publisher

Walter de Gruyter GmbH

Subject

Safety, Risk, Reliability and Quality,General Materials Science,Nuclear Energy and Engineering,Nuclear and High Energy Physics,Radiation

Link

https://www.degruyter.com/document/doi/10.3139/124.110118/pdf

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