Author:
Hussain Dr Zakir,Suresh Dr Mukkamalla,Hemalata B.,Shireen Shaik
Abstract
The concept of formulating sustained release tablets using different polymers offers a suitable and practical approach of sustained in release and dissolution characteristics. Here the solubility of Dextromethorphan is enhanced by solid dispersions with PEG6000 as carrier. Then the formed solid dispersions are characterized and evaluated by drug content and In vitro dissolution studies. Among the various s solid dispersions prepared, the formulation SDF2 i.e., the solid dispersion of Dextromethorphan with PEG6000 prepared by Solvent Evaporation method shows faster dissolution rate it was decided to use formulations SDF2 to formulate sustained release tablets using different polymers like HPMC, EC and Guar gum by direct compression technique. Optimized formulation F4 which includes HPMC and EC has successfully sustained the drug release. The release process involves anomalous diffusion mechanism or diffusion coupled with erosion. FTIR studies show that there is compatibility between drug and excipients for the developed matrix tablets.
Reference28 articles.
1. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism;"1. BJ. Aungst;J Pharm Sci,1993
2. 2. KPR. Chowdary. Investigation of dissolution enhancement of itraconazole by complexation with β-cyclodextrin and hydroxypropyl β-cyclodextrin. Indian J Pharm Sci. 2001;438-441.
3. Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology;Hargreaves;Acta Neurochir Suppl (Wien),1994
4. 4. SC. Hernandez, Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors. J Pharmacol Exp Ther. 2000 Jun;293(3):962-7.
5. 5. JW. Olney, J Labruyere. Price MT: Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science. 1989 Jun 16;244(4910):1360-2.