Fuzzy: a genetic marker for warfarin resistance in the Norway rat

Author:

Greaves J. H.1,Ayres Priscilla B.1

Affiliation:

1. Tolworth Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey KT6 7NF, UK

Abstract

No recombination was observed between fuzzy ( fz) and warfarin resistance ( Rww) in 245 rats from a backcross test for linkage. This locates fz very close to Rw in linkage group I. The map position established for fz makes this allele particularly suitable for use in combination with p (pink-eyed dilution) for linkage tests in group I and as a genetic marker for the Rw locus in studies of warfarin resistance. The map position of fz in the rat corresponds to that of fr (frizzy) in the mouse, suggesting homology between these loci in the 2 species.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

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