Development of heart and aortic lesions in DBA/2NCrj mice-Reference-Cited by-同舟云学术

Development of heart and aortic lesions in DBA/2NCrj mice

Published:1986-01-01 Issue:1 Volume:20 Page:5-8
ISSN:0023-6772
Container-title:Laboratory Animals
language:en
Short-container-title:Lab Anim

Author:

Maeda N.¹,Doi K.¹,Mitsuoka T.¹

Affiliation:

1. Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo, Bunkyo, Tokyo 113, Japan

Abstract

The development of heart and aortic lesions was investigated in 3- to 8-week-old DBA/2NCrj mice. In the heart, small foci of myocardial calcification and severe calcification with subsequent inflammation were observed. Severe lesions were restricted to the myocardium below the right ventricular epicardium. Small foci of myocardial calcification were found from 4 to 8 weeks of age with almost the same frequency. The incidence of severe calcification showed a drastic increase between 6 and 7 weeks of age. Aortic lesions were observed from 3 weeks of age and characterized by focal calcification of the smooth muscle cells and elastic laminae. The frequency of aortic calcification was about 50% and not age-related.

Publisher

SAGE Publications

Subject

General Veterinary,Animal Science and Zoology

Link

http://journals.sagepub.com/doi/pdf/10.1258/002367786781062151

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