Focal sources of FGF-10 promote the buckling morphogenesis of the embryonic airway epithelium

Author:

Peak Kara E.1,Mohr-Allen Shelby R.1,Gleghorn Jason P.2,Varner Victor D.13ORCID

Affiliation:

1. University of Texas at Dallas 1 Department of Bioengineering , , Richardson, TX 75080 , USA

2. University of Delaware 2 Department of Biomedical Engineering , , Newark, DE 19716 , USA

3. UT Southwestern Medical Center 3 Department of Surgery , , Dallas, TX 75390 , USA

Abstract

ABSTRACT During airway branching morphogenesis, focal regions of FGF-10 expression in the pulmonary mesenchyme are thought to provide a local guidance cue, which promotes chemotactically the directional outgrowth of the airway epithelium. Here, however, we show that an ectopic source of FGF-10 induces epithelial buckling morphogenesis and the formation of multiple new supernumerary buds. FGF-10-induced budding can be modulated by altered epithelial tension and luminal fluid pressure. Increased tension suppresses the formation of ectopic branches, while a collapse of the embryonic airway promotes more expansive buckling and additional FGF-10-induced supernumerary buds. Our results indicate that a focal source of FGF-10 can promote epithelial buckling and suggest that the overall branching pattern cannot be explained entirely by the templated expression of FGF-10. Both FGF-10-mediated cell behaviors and exogenous mechanical forces must be integrated to properly shape the bronchial tree.

Funder

National Institutes of Health

University of Texas at Dallas

Publisher

The Company of Biologists

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Reference57 articles.

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