The mechanical and morphological properties of systemic and pulmonary arteries differ in the Madagascar ground boa, a snake without ventricular pressure separation

Author:

van Soldt Benjamin J.1ORCID,Wang Tobias2ORCID,Filogonio Renato3ORCID,Danielsen Carl Christian4

Affiliation:

1. Gladstone Institute of Cardiovascular Disease, J. David Gladstone Institutes 1 , 1650 Owns Street, San Francisco, CA 94158 , USA

2. Aarhus Institute of Advanced Sciences (AIAS), Aarhus University 2 , 8000 Aarhus C , Denmark

3. Federal University of São Carlos 3 Department of Physiological Sciences , , São Carlos, SP 13565-905 , Brazil

4. University of Aarhus 4 Department of Biomedicine , , Wilhelm Meyers Allé 3, 8000 Aarhus C , Denmark

Abstract

ABSTRACT The walls of the mammalian aorta and pulmonary artery are characterized by diverging morphologies and mechanical properties, which have been correlated with high systemic and low pulmonary blood pressure, as a result of intraventricular pressure separation. However, the relationship between intraventricular pressure separation and diverging aortic and pulmonary artery wall morphologies and mechanical characteristics is not understood. The snake cardiovascular system poses a unique model for the study of this relationship, as representatives both with and without intraventricular pressure separation exist. In this study, we performed uniaxial tensile testing on vessel samples taken from the aortas and pulmonary arteries of the Madagascar ground boa, Acrantophis madagascariensis, a species without intraventricular pressure separation. We then compared these morphological and mechanical characteristics with samples from the ball python, Python regius, and the yellow anaconda, Eunectes notaeus – species with and without intraventricular pressure separation, respectively. Our data suggest that although the aortas and pulmonary arteries of A. madagascariensis respond similarly to the same intramural blood pressure, they diverge in morphology, and that this attribute extends to E. notaeus. In contrast, P. regius aortas and pulmonary arteries diverge both morphologically and in terms of their mechanical properties. Our data indicate that intraventricular pressure separation cannot fully explain diverging aortic and pulmonary artery morphologies. Following the law of Laplace, we propose that pulmonary arteries of small luminal diameter represent a mechanism to protect the fragile pulmonary vasculature by reducing the blood volume that passes through, to which genetic factors may contribute more strongly than physiological parameters.

Funder

Det Frie Forskningsråd|Natur og Univers

Leiden University Fund

Koninklijke Nederlandse Dierkundige Vereniging

Outbound Study Grant

Fundação de Amparo à Pesquisa do Estado de São Paulo

Erasmus

Publisher

The Company of Biologists

Subject

Insect Science,Molecular Biology,Animal Science and Zoology,Aquatic Science,Physiology,Ecology, Evolution, Behavior and Systematics

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Ontogenetic scaling of the baroreflex function in the green iguana (Iguana iguana);American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;2022-12-01

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