An update on nuclear calcium signalling
Author:
Bootman Martin D.1, Fearnley Claire1, Smyrnias Ioannis1, MacDonald Fraser2, Roderick H. Llewelyn13
Affiliation:
1. Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB22 3AT, UK 2. KCL Dental Institute, Department of Orthodontics, St Thomas Street, London SE1 9RT, UK 3. Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
Abstract
Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca2+) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca2+ activity, and vice versa. In this Commentary, we describe mechanisms of nuclear Ca2+ signalling and discuss what is known about the origin and physiological significance of nuclear Ca2+ transients. In particular, we focus on the idea that the nucleus has an autonomous Ca2+ signalling system that can generate its own Ca2+ transients that modulate processes such as gene transcription. We also discuss the role of nuclear pores and the nuclear envelope in controlling ion flux into the nucleoplasm.
Publisher
The Company of Biologists
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