A comprehensive study of phospholipid fatty acid rearrangements in the metabolic syndrome: correlations to organ dysfunction

Author:

Bacle Amélie1,Kadri Linette1,Khoury Spiro1,Ferru-Clément Romain1,Faivre Jean-François12,Cognard Christian2,Bescond Jocelyn2,Krzesiak Amandine2,Contzler Hugo2,Delpech Nathalie3,Colas Jenny12,Vandebrouck Clarisse12,Sébille Stéphane12,Ferreira Thierry1ORCID

Affiliation:

1. Laboratoire “Lipotoxicity and Channelopathies (LitCh) - ConicMeds”, Université de Poitiers, 1, rue Georges Bonnet, Poitiers, France

2. Laboratoire “Signalisation et Transports Ioniques Membranaires (STIM; EA 7349)“, Université de Poitiers, 1, rue Georges Bonnet, Poitiers, France

3. Laboratoire “Mobilité Vieillissement et Exercice (MOVE; EA 6314)“, Université de Poitiers, 8, Allée Jean Monnet, Poitiers, France

Abstract

The balance within phospholipids (PL) between Saturated Fatty Acids (SFA) and mono- or poly- Unsaturated Fatty Acids (UFA), is known to regulate the biophysical properties of cellular membranes. As a consequence, perturbating this balance alters crucial cellular processes in many cell types, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spreading of the Western-diet, which is specifically enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome, known as the Metabolic Syndrome (MetS), which is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis. However, no clear correlations between diet-induced fatty acid redistribution within cellular PL, the severity/chronology of the symptoms associated to MetS and the function of the targeted organs have been established. In an attempt to fill this gap, we analyzed in the present study PL remodeling in rats exposed during 15 weeks to a High Fat/High Fructose diet (HFHF) in several organs, including known MetS targets. We show that fatty acids from the diet can distribute within PL in a very selective way, with PhosphatidylCholine being the preferred sink for this distribution. Moreover, in the HFHF rat model, most organs are protected from this redistribution, at least during the early onset of MetS, at the exception of the liver and skeletal muscles. Interestingly, such a redistribution correlates with clear-cut alterations in the function of these organs.

Funder

European Regional Development Fund

Publisher

The Company of Biologists

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology (miscellaneous),Medicine (miscellaneous),Neuroscience (miscellaneous)

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3