Distribution of H3K27me3, H3K9me3, and H3K4me3 along autophagy-related genes highly expressed in starved zebrafish myotubes

Author:

Biga Peggy R.1ORCID,Latimer Mary N.1,Froehlich Jacob Michael1,Gabillard Jean-Charles2,Seiliez Iban3

Affiliation:

1. Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA

2. INRA, UR1037 Laboratory of Fish Physiology and Genomics, Campus de Beaulieu, Rennes, F-35042, France

3. INRA-UPPA, UMR1419 Nutrition Metabolisme Aquaculture, F-64310 St-Pée-sur-Nivelle, France

Abstract

The zebrafish (Danio rerio) remains the teleost fish of choice for biological investigations due to the vast array of molecular tools and resources available. To better understand the epigenetic regulation of autophagy, we utilized a primary myotube culture system generated from isolated myogenic precursor cells (MPCs) from zebrafish grown under starvation conditions using a media devoid of serum and amino acids. Here, we report starvation-induced regulation of several autophagy-related genes (atg) expression and profile the distribution of H3K27me3, H3K9me3, and H3K4me3 marks along lc3b, atg4b and p62/sqstm1 loci. These data support epigenetic regulation of autophagy in response to starvation that suggests a level of regulation that can be sustained for chronic conditions via chromatin modification.

Funder

Foundation for the National Institutes of Health

Publisher

The Company of Biologists

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

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