Affiliation:
1. Institut de Biologie du Développement de Marseille, Aix-Marseille Université, CNRS UMR 7288, Campus de Luminy, 13009 Marseille, France
Abstract
Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actin filaments, actin cross-linkers and myosin motors. The subcellular forces generated by such actomyosin networks are precisely regulated and are transmitted to the cell cortex of adjacent cells and to the extracellular environment by adhesive clusters comprising cadherins or integrins. Here, and in the accompanying poster, we provide an overview of the mechanics, principles and regulation of actomyosin-driven cellular tension driving tissue morphogenesis.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
188 articles.
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