Sphingolipid organization in biomembranes: what physical studies of model membranes reveal-Reference-Cited by-同舟云学术

Sphingolipid organization in biomembranes: what physical studies of model membranes reveal

Published:1998-01-01 Issue:1 Volume:111 Page:1-9
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

Brown R.E.¹

Affiliation:

1. The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.

Abstract

Recent cell biological studies suggest that sphingolipids and cholesterol may cluster in biomembranes to form raft-like microdomains. Such lipid domains are postulated to function as platforms involved in the lateral sorting of certain proteins during their trafficking within cells as well as during signal transduction events. Here, the physical interactions that occur between cholesterol and sphingolipids in model membrane systems are discussed within the context of microdomain formation. A model is presented in which the role of cholesterol is refined compared to earlier models.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/111/1/1/1352372/1.pdf

Reference105 articles.

1. On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: physiologic concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes.;Ahmed;Biochemistry,1997

2. Lateral diffusion and percolation in two-phase, two-component lipid bilayers. Topology of the solid-phase domains in-plane and across the lipid bilayer.;Almeida;Biochemistry,1992

3. Percolation and diffusion in three-component lipid bilayers: effect of cholesterol on an equimolar mixture of two phosphatidylcholines.;Almeida;Biophys. J,1993

4. Caveolae, where incoming and outgoing messengers meet.;Anderson;Proc. Nat. Acad. Sci. USA,1993

5. Calorimetric studies on various gangliosides and ganglioside-lipid interactions.;Bach;Biochim. Biophys. Acta,1982

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