Affiliation:
1. Vertebrate Development and Genetics, Wellcome Trust Sanger Institute,Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Abstract
The notochord is the defining structure of the chordates, and has essential roles in vertebrate development. It serves as a source of midline signals that pattern surrounding tissues and as a major skeletal element of the developing embryo. Genetic and embryological studies over the past decade have informed us about the development and function of the notochord. In this review, I discuss the embryonic origin, signalling roles and ultimate fate of the notochord, with an emphasis on structural aspects of notochord biology.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
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