Stephen Weinberg posited in 1977 that as the universe becomes more comprehensible, it appears more meaningless owing to a strict division between facts and values. He seemingly overlooked the consideration of the purposes and values of intelligent life in examining its ability to influence the universe's development. The scientific revolution, initiated by Copernicus's heliocentric hypothesis and furthered by Darwin's theory, shifted humanity's perceived place in the cosmos, removing the sacred. However, developments in astrobiology and discoveries related to the Fermi Paradox and the Rare Earth Hypothesis are hinting at humanity's significant role in the universe, suggesting we might be the only intelligent species. This paper argues that advancing scientific knowledge reinforces the hypothesis of human exclusivity and importance in the cosmos, making the potential sixth mass extinction cosmically significant and underscoring the imperative of human persistence in the cosmos.