Human resource information systems (HRISs) are widely used and have a strategic impact on organizations. The fundamental objective of this paper is to reveal the predominant antecedents affecting their adoption and implementation by replicating the unified theory of acceptance and use of technology (UTAUT) model from a South Asian emergent country perspective. The study collected data from human resource professionals employed in manufacturing and service companies located in Bangladesh, which were analyzed by employing partial least squares-based structural equation modeling software. It was revealed that performance expectancy, social pressure, and facilitation conditions significantly influence the intention to use and the actual use of HRIS, but that user’s effort expectancy had no significant impact. The study contributes by enriching the previous findings and validating the results based on relevant literature. Furthermore, managerial implications, the limitations of the study and suggested future study directions are presented.