Comparison of Two Oxytocin Doses for Optimal Uterine Tone During Cesarean Delivery

Abstract

The optimum oxytocin dosage schedule for caesarean sections depends on uterine tone, maternal hemodynamics, and safety. This study compares a continuous 20 IU infusion (Group B) versus a 3 IU bolus followed by a 10 IU per hour infusion during elective caesarean delivery to determine their efficacy and safety (Group A). Two groups of sixty elective caesarean patients were randomly assigned. Uterine tone, maternal hemodynamics, uterotonic drug need, and side effects were assessed. The two dosing schedules were statistically compared. Five minutes post-oxytocin administration, Group A had significantly higher uterine tone than Group B (p < 0.001). Although not statistically significant, Group B maternal hemodynamics showed lower systolic and diastolic blood pressure. The groups had similar adverse effects and uterotonic drug needs. Despite the fast uterine tone of the bolus + infusion regimen, maternal hemodynamics must be regulated. Both regimens were safe; however, a customised dose may be needed. Clinical settings and patient characteristics are critical. This study shows how quickly uterine tone may be achieved following elective caesarean surgery using a 3 IU bolus and 10 IU oxytocin each hour. Maternal hemodynamics and uterotonic efficacy should inform dosing recommendations, with an emphasis on customised techniques.