Affiliation:
1. DIPSAR, India
2. AIMST University, Malaysia
3. College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Saudi Arabia
Abstract
Studies recognize amyotrophic lateral sclerosis (ALS) as a neurodegenerative illness attributed to motor neuron loss. The mechanics of neurodegenerative disorders are multifactorial and complex. Evidence suggests some commonly shared pathways, like mitochondrial dysfunctioning, intracellular Ca2+ overload, inflammation, and oxidation stress. Often multiple pathways coexistence offer limitations for therapeutic interventions. Several clinical and preclinical studies report the relation between nutrional state and ALS. Nutrition management in ALS is quite complex, as during ALS the physical, physiological, and psychological effects must be considered and addressed. Due to limited medications, careful attention over nutrition imposes positive impact on the course of the disease. Nutrition-based methodologies focus on different pathways in a progressive physiological manner without causing extreme adverse impacts. Based on research focusing on improvement of prognosis and dietary interventions for ALS symptoms, many patients seek nutraceuticals or dietary nature complementary/alternative medicines.