Strategies to Suppress Tumor Angiogenesis and Metastasis, Overcome Multi-Drug Resistance in Cancer, Target Telomerase and Apoptosis Pathways

Abstract

Cancer has been a worldwide topic in the medical field for a very long time. As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. In cancer patients, multidrug resistance (MDR) is most widely used phenomenon by which cancer acquired resistance to chemotherapy. This resistance to chemotherapy occurs due to the formation of insulated tumor microenvironment which remains a major hurdle in the cure of various types of cancer. The mechanisms that cause malignant growth of cells include cell cycle control, signal transduction pathways, apoptosis, telomere stability, and interaction with the extracellular matrix. This chapter focuses on current strategies to suppress tumor angiogenesis for cancer therapy, various mechanisms involved in the development of MDR in cancer cells, which in turn will help us to identify possible strategies to overcome these MDR mechanisms and a variety of procedures that involves targeting apoptotic and telomerase pathways to suppress tumor progression.