While many eHealth innovation projects have emerged in the last few years, most of them remain as pilot projects. The purpose of this study is to improve our understanding of what conditions prevent these projects from not being implemented. Using a qualitative methodology, based on case studies, the authors studied projects that have been implemented and others that have remained pilots to compare what factors determine the real implementation. Four conditions emerge from the analysis that seem to have a great influence on their implementation: technological anxiety, facilities (specifically changes in developments), training, and social influence, particularly when training is given by health professionals who are part of the pilot project to other colleagues. This work highlights a set of actions that should be implemented in eHealth innovation projects and also provides a basis for defining strategies to reduce the risk of increasing the phenomenon of plague of pilot, increasing the success rate in the implementation of the projects.