Integrated learning has attracted much attention from industry and academia. In the new era, colleges and universities need to discuss information management in light of actual conditions, integrate different data in each information system into the same database, so as to form a data warehouse based on the integrated database which can truly reflect the historical changes of data and provides support for managers' decision-making. This paper analyzes the clustering effect of standard differential evolution algorithm, improved differential evolution algorithm and K-means algorithm. The algorithm is tested using Iris and Wine database marts, the results show that the K-means algorithm is a relatively poor algorithm and its accuracy is significantly lower than the other two. Based on big data, multi-factor interactive variance analysis technology is used to analyze different data indicators and influencing factors. Therefore, colleges and universities can use the database to better understand the problems and advantages in management, thus to improve management efficiency and teaching level.