Abstract
Objective: Pseudoexfoliation syndrome (PEX) occurs as a result of aggregation of extracellular matrix material in ocular tissues and visceral organs and it is known as a systemic disease. The purpose of our study is to investigate the activities of carbonic anhydrase (CA), glutathione reductase (GR), aldose reductase (AR), paraoxonase (PON) enzymes in aqueous and serum samples, also serum selenium levels.
Methods: Serum and aqueous samples from 33 PEX and 33 control subjects were collected. Enzyme activities were studied in both serum and aqueous samples by biochemical methods.
Results: According to the results, serum CA hydratase enzyme activity levels were higher in the samples with PEX compared to the control samples (p < 0.05). Aqueous CA hydratase and aqueous/serum PON, GR and AR activity levels did not differ significantly among the study samples (p > 0.05).
Conclusions: Based on the relationship of carbonic anhydrase with aqueous production and glaucoma, increased CA hydratase activity may help to understand the etiopathogenesis and mechanism of conversion to glaucoma of PEX. In the literature, we did not find a study on activity of CA in aqueous and serum samples in patients with PEX. Therefore, we believe that this study can be a reference.
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference58 articles.
1. Damji KF, Bains HS, Amjadi K, Dohadwala AA, Valberg JD, Chevrier R, et al. Familial occurrence of pseudoexfoliation in Canada. Can J Ophthalmol. 1999;34(5),257-265.
2. Konstas AG, Williamson TH. Coexistence of exfoliation syndrome, previous iris surgery and heterochromia. Acta Ophthalmol. 1993; 71(6),850-852.
3. Orr AC, Robitaille JM, Price PA, Hamilton JR, Falvey DM, De Saint-Sardos AG, et al. Exfoliation syndrome: clinical and genetic features. Ophthalmic Genet. 2001;22(3),171-185.
4. Ringvold A, Blika S, Elsas T, Guldahl J, Brevik T, Hesstvedt P, et al. The Middle-Norway eye-screening study. I. Epidemiology of the pseudo-exfoliation syndrome. Acta Ophthalmol. 1988;66(6):652-8.
5. Koliakos GG, Befani CD, Mikropoulos D, Ziakas NG, Konstas. AGP. Prooxidant–antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. Graefes Arch Clin Exp Ophthalmol. 2008;246:1477–1483.