Chemical Analysis of the Main Groups of Biologically Active Substances in Sedative Collection

Abstract

Introduction. According to the World Health Organization, the number of patients with diseases of the nervous system in the world is increasing every year. The use of phytopreparations is a promising direction of pharmacotherapy; preparations from medicinal plant materials have a number of advantages in the treatment of chronic diseases.Aim. Qualitative analysis and quantitative determination of the main groups of biologically active substances collected from medicinal plant materials.Materials and methods. As an object of study, we used a collection of medicinal plant materials developed at the Department of Pharmaceutical Technology of the PSFA together with the Department of Pharmacognosy. Quantitative determination of biologically active substances of the collection was carried out by spectrophotometric method [Jenway PortLab 511 UV spectrophotometer PortLab Int., UK)] and by visual titration.Results and discussion. In this work, a qualitative analysis and quantitative determination of the content of flavonoids, phenolic compounds, sesquiterpenic acids and ascorbic acid was carried out, and the water absorption coefficient of the collection was determined.Conclusion. As a result of the work, the content of flavonoids, phenolic compounds, sesquiterpenic acids and ascorbic acid in the developed collection was confirmed, their amount was determined, which directly affects the pharmacological effect of the collection.