Affiliation:
1. Abhinav Education Society’s College of Pharmacy, Narhe, Pune
Abstract
Vericiguat is a novel oral soluble guanylate cyclase (sGC) stimulator used in the treatment of chronic heart failure, aimed at reducing hospitalization rates and improving cardiac function by inducing vasodilation. The analysis of Vericiguat in pharmaceutical formulations and biological fluids requires robust and precise analytical methods. High-Performance Liquid Chromatography (HPLC) and UV-Visible Spectrophotometry are the primary techniques employed for this purpose due to their high specificity, sensitivity, and rapid analysis capabilities. This review discusses the development, validation, and application of these analytical methods for Vericiguat. Various HPLC methods have been developed, utilizing different columns, mobile phases, and detection wavelengths to ensure the accurate quantification of Vericiguat in bulk and tablet dosage forms. UV-Visible spectrophotometry has also been employed, offering a simpler and cost-effective alternative for routine analysis. The review consolidates the key parameters and findings of these methods, highlighting their advantages and suitability for the effective analysis of Vericiguat, thereby contributing to quality assurance in pharmaceutical development and therapeutic monitoring
Reference21 articles.
1. Prajapati Foram and Priyanka Yadav (2023). STABILITY INDICATING HPLC METHOD DEVELOPMENT AND VALIDATION OF VERICIGUAT IN TABLET DOSAGE FORM, WJPPS, Volume 12, Issue 7, 420-429.
2. Vericiguat (no date) Uses, Interactions, Mechanism of Action Drug Bank Online. Available at: https://go.drugbank.com/ drugs/DB15456.
3. Kang C. and Lamb YN. Vericiguat: A review in chronic heart failure with reduced ejection fraction. American Journal of Cardiovascular Drugs. Vol 22 issue 4, pp. 451– 459, 2022.
4. Ema Verquvo. European Medicines Agency. Available at: https://www.ema.europa.eu/en/medicines/human/EPAR /verquvo, 2021.
5. Verquvo® (vericiguat) employs a novel moa for the treatment of HF, resulting in smooth muscle relaxation and Vasodilation1 (no date) Mechanism of Action (MOA) of Verquvo® (vericiguat). Available at: https://www.merckconnect.com /verquvo/mechanismof-action.