Distribution of Polymorphic Markers of Genes Encoding the Renin-angiotensin System (ACE, AGT, AGTR1), ITGB3, PPARG, Pparg in Patients With Essential Hypertension Depending on the Age

Author:

Zotova Tatyana1,Azova Madina2,Lukanina Anastasia1,Aissa A. Ait2,Blagonravov Mikhail1

Affiliation:

1. A. Frolov Department of General Pathology and Pathological Physiology, Peoples’ Friendship University of Russia (RUDN University), Institute of Medicine, 6, Miklukho-Maklaya Str., Moscow, 117198, RUSSIAN FEDERATION

2. Department of Biology and General Genetics, Peoples’ Friendship University of Russia (RUDN University), Institute of Medicine, 6, Mikukho-Maklaya Str., Moscow, 117198, RUSSIAN FEDERATION

Abstract

Essential hypertension (EH) is a multifactorial disease with a hereditary predisposition. Genes encoding the renin-angiotensin system (RAS) play a leading role in the stabilization of elevated BP in the course of EH, which determines the relevance of our clinical and genetic study. The study was based on the determination of the frequencies of polymorphic markers of the AGT, AGTR1, ACE, ITGB3, PPARG genes in 2 groups, depending on the age of patients (up to 60 years - group1, n=18, and after 60 years - group2, n=31), for the intergroup frequencies comparison and comparison of group frequencies with population data. Genotyping by gene polymorphisms was performed by real-time polymerase chain reaction. 24-hour ambulatory BP monitoring (ABPM) and Holter HR monitoring were conducted. Phenotypic features of the course of EH were accompanied by changes in the frequency characteristics of the studied genotypes. In patients of group 1, an increase in the frequency of protective genotypes of the ACE(II) and ITGB3(TT) genes was observed (p=0.004;0.015), which confirms the hypothesis of a possible favorable course of EH in patients under 60 years.

Publisher

North Atlantic University Union (NAUN)

Subject

General Biochemistry, Genetics and Molecular Biology,Biomedical Engineering,General Medicine,Bioengineering

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