Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines-Reference-Cited by-同舟云学术

Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines

Published:2022-02 Issue:2 Volume:8 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Sergazy Shynggys¹,Vetrova Anastassiya²^ORCID,Orhan Ilkay Erdogan³,Senol Deniz Fatma Sezer³,Kahraman Ahmet⁴,Zhang Jian-Ye⁵,Aljofan Mohamad²^ORCID

Affiliation:

1. National Laboratory Astana, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan

2. Department of Biomedical Science, Nazarbayev University School of Medicine, Nur-Sultan, 010000, Kazakhstan

3. Department of Pharmacognosy, Gazi University, Ankara, 06330, Turkey

4. Department of Biology, Usak University, 64200 Usak, Turkey

5. Key Laboratory of Molecular Target & Clinical Pharmacology & the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, P.R. China

Abstract

Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.

Funder

Nazarbayev University Collaborative Research

School of Medicine Nazarbayev University

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2021-0109

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