Case report: gastrointestinal stromal tumour (GIST) in the small intestine

Abstract

The analysis of contemporary scientifi literature, clinical recommendations, and the identifiation of challenges in the diagnosis, treatment, and postoperative care of patients encountered by non-oncology physicians are conducted. Gastrointestinal stromal tumors (GISTs) are neoplasms originating from the gastrointestinal tract’s mesenchymal cells, particularly from interstitial Cajal cells. They hold an intermediate position between benign and malignant tumors, occurring at a rarity rate of approximately 1 to 3 %. The description of this pathology in both domestic and foreign literature is infrequent. A clinical case description from personal practice is presented, detailing the assessment of preoperative research methods and surgical tactics, along with the results of histological and immuno-histochemical studies. An important aspect in the postoperative period involves assessing the risk of tumour recurrence and metastasis. Notably, GISTs are characterized by the absence of lymphogenic metastasis and an extremely low frequency of infitrative growth. Thus, it is now a common practice to perform resections without lymph node dissection. The primary method for defiitive diagnosis confimation is an immuno-histochemical study, crucial for determining the indications for targeted therapy. The rare incidence of GISTs in the small intestine in non-oncological medical practice, compounded by the limitations of endoscopic imaging methods for the small intestine, poses challenges in establishing a diagnosis during the outpatient examination.