SYNTHESIS, CHARACTERIZATION AND SKELETAL MUSCLE RELAXANT ACTIVITY FOR NOVEL [1,4]DIAZEPINO[2,3-G]QUINOXALINE DERIVATIVES-Reference-Cited by-同舟云学术

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SYNTHESIS, CHARACTERIZATION AND SKELETAL MUSCLE RELAXANT ACTIVITY FOR NOVEL [1,4]DIAZEPINO[2,3-G]QUINOXALINE DERIVATIVES

Published:2020-11-05 Issue:09 Volume:57 Page:38-44
ISSN:0019-462X
Container-title:INDIAN DRUGS
language:
Short-container-title:IND. DRU.

Author:

Visagaperumal D.,Varma Pemmadi Raghuveer,Jayakumar R.,Chandy Vineeth

Abstract

Novel [1,4]diazepino[2,3-g]quinoxaline derivatives 5a-5i were designed, synthesized and characterized by spectroscopic method and elemental analysis. The title compounds were screened for skeletal muscle relaxant. Among the synthesized analogs, compound 5g and compound 5h revealed significant skeletal muscle relaxant activity. The relationship between the functional group variation and the biological activity of the synthesized compounds is discussed.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

Reference22 articles.

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2. 2. Fryer R.I., In: Taylor, E.C. (Eds), Bicyclic Diazepines. Wiley, Newyork, 1991, pp. 50.

3. 3. De Baun J.R., Pallos F.M., Baker D.R., US Patent 3, 978, 227, 1976; Chem Abstr 1977, 86, 5498d.

4. 4. Randall L.O., Kapple B., In benzodiazepines. In: Garattini S, Musini E, Randall L.O.

5. (Eds). Raven Press, Newyork,1977.

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