IN VITRO ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF DESMODIUM TRIFLORUM-Reference-Cited by-同舟云学术

IN VITRO ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF DESMODIUM TRIFLORUM

Published:2019-07-28 Issue:07 Volume:56 Page:76-79
ISSN:0019-462X
Container-title:INDIAN DRUGS
language:en
Short-container-title:IND. DRU.

Author:

Revanasiddappa B.C,Vijay Kumar M.,Shanmukha I.,Kumar H,Aishwarya T. C,

Abstract

The ethanolic extract of Desmodium triflorum (EEDT) was investigated for in vitro antiurolithiatic activity by using nucleation and aggregation methods. phytochemical screening was also undertaken to reveal the presence of alkaloids, flavonoids, reducing sugars and sterols in the sample. The In vitro studies showed that the ethanolic extract inhibits aggregation, nucleation and growth of calcium oxalate crystals. The extract exhibited inhibitory action in both nucleation and aggregation assays at significant level. The results of nucleation assay were found to be significant and showed inhibition (60.39%) compared to standard cystone drug (79.59%) and in aggregation assay also showed inhibition (70.89%) compared to cystone (79.22%) at 500μgm/ml concentration. The results clearly indicated that EEDT has the capacity to inhibit the crystal formation and aggregation.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

Link

https://www.indiandrugsonline.org//download/July_2019_56_07_76-79.pdf

Reference26 articles.

1. 1. Rahul Jha., Ramani P.T., Patel D., Desai S., Meshram D. Phytochemical analysis and In- vitro urolithiasis activity of Peltophorum pterocarpum leaves (DC) Baker. J. Med. Plants. Studies., 2016, 4(3): 18-22.

2. 2. Kyada A., Mansuri N., Patel P. In vitro investigation of some alternative therapeutic agents for antiurolithiatic activity. J.Pharm. Res., 2017, 11(8): 955-61.

3. 3. Phatak S.R., Hendre A.S. In-Vitro antiurolithiatic activity of Kalanchoe Pinnata extract. Int. J. Pharmacog. Phytochem. Res., 2015, 7(2): 275-79.

4. 4. Saxena N., Argal A. Study of antiurolithiatic activity of a formulated herbal suspension. Herba. Pol., 2015, 61(2): 41-49.

5. 5. Reddy C.S., Vardhaman P. Evaluation of Phoenix dactylifera fruits for antiurolithiatic activity. Hygeia.J.D.Med., 2013, 5(1): 135-40.